Endocrine Abstracts

Introduction: Hypoaldosteronism can be induced by a deficit of aldosterone production (AldDef) or a mineralocorticoid resistance (MinRes). Experts have proposed to use hyperkalemia-based aldosterone values for this purpose. However, there is no a range of aldosterone values indicating one of this type of hypoaldosteronism. In 2008, Adam W. R.1 hypothesized that the factored aldosterone (FAldo) could be useful differentiating hypoaldosteronism secondary to MinRes fro...

Introduction: Endocrine Society guideline indications for screening (EGS) of hypertensive patients for hyperaldosteronism are not universally followed in clinical Endocrinology. We present a series of patients with hyperaldosteronism, diagnosed following strict EGS compliance.Methods: Retrospective. Following compliance with EGS in all patients attended in a general Endocrinology outpatient clinic, 70 hypertensive patients were diagnosed with hyperaldost...

Measurement of electrical impedance has been proposed as a way to determine whether a hyponatremic patient is hypovolemic or euvolemic. We compare the usefulness of the physical examination (PE) with bioimpedance for determination of volemia in an outpatient hyponatremia clinic.Method: Descriptive prospective analysis. 11 patients attended at the hyponatremia clinic of a tertiary hospital were evaluated. Impedance was measured by a SECA, indicating the p...

Low-renin hypertension (LRH) with normal or elevated aldosterone levels is considered part of the spectrum of aldosterone-associated hypertension, and can cause poorly-controlled hypertension. We studied patients diagnosed with LRH, comparing their clinical and biochemical characteristics with patients diagnosed with primary hyperaldosteronism (PHA). Methods Retrospective. Diagnosis in a general Endocrinology out-patient clinic ove...

Acquired Hypoaldosteronism may be caused by low circulating aldosterone levels (AD), resistance to mineralocorticoid action (MR), or a combination of both (CB). We describe the clinical/biochemical characteristics of these three types of hypoaldosteronism. Methods Retrospective review of a series of 177 patients with acquired hypoaldosteronism assessed by the Endocrinology Department of a tertiary teaching hospital from 2012 to 201...

Introduction: Amiodarone-induced thyrotoxicosis (AIT) occurs in up to 6% of patients taking this medication in iodine sufficient areas and in up to 10% of patients in iodine deficient areas and has a high rate of mortality, that can reach 50% in untreated severe forms. There are two main types (1 and 2) described, although usually we find mixed types, with both components. Below, we describe the cases of two brothers that developed severe mixed forms of amiodarone-induced thyr...

Introduction: Admission hyponatremia, frequently detected in patients hospitalized for COVID-19, has been associated with increased mortality. However, although SIADH-induced euvolemic hyponatremia is the single most-common cause of hyponatremia in community-acquired pneumonia, repercussions of admission-hyponatremia volemic classification on COVID-19 hospitalizations have yet to be described. We sought to identify factors contributing to mortality and hospital length-of-stay ...

Introduction: Clinical trials indicate that Tolvaptan is safe and effective in the treatment of patients with sustained mild/moderate SIADH-induced euvolemic hyponatremia. Tolvaptan doses are often modified during chronic use. We present the weekly doses of a series of patients on chronic therapy, followed up in outpatient clinic.Methods: Retrospective, cross-sectional. 114 patients receiving tolvaptan for chronic SIADH were followed up in a Hyponatremia...

Introduction Institutional campaigns, and some health care professionals, encourage the elderly to drink large quantities of fluids, regardless of their level of thirst. Furthermore, SIADH-inducing medications can often cause dryness of mouth. Thus, patients when diagnosed with SIADH can have a high fluid intake (FI), drinking in the absence of thirst. However, fluid restriction, considered the first step in therapy of mild/moderate SIADH hyponatremia, h...